Regulation of global gene expression and cell proliferation by APP

  title={Regulation of global gene expression and cell proliferation by APP},
  author={Yili Wu and Si Zhang and Qin Xu and Haiyan Zou and Weihui Zhou and F. F. Cai and Tingyu Li and Weihong Song},
  booktitle={Scientific reports},
Down syndrome (DS), caused by trisomy of chromosome 21, is one of the most common genetic disorders. Patients with DS display growth retardation and inevitably develop characteristic Alzheimer's disease (AD) neuropathology, including neurofibrillary tangles and neuritic plaques. The expression of amyloid precursor protein (APP) is increased in both DS and AD patients. To reveal the function of APP and elucidate the pathogenic role of increased APP expression in DS and AD, we performed gene… CONTINUE READING


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