Regulation of global and specific mRNA translation by oral administration of branched-chain amino acids.

@article{Kimball2004RegulationOG,
  title={Regulation of global and specific mRNA translation by oral administration of branched-chain amino acids.},
  author={Scot R. Kimball and Leonard S. Jefferson},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={313 2},
  pages={423-7}
}
The importance of branched-chain amino acids as nutrient regulators of protein synthesis in skeletal muscle was recognized more than 20 years ago. Of the branched-chain amino acids, leucine in particular was shown to play a central role in promoting muscle protein synthesis. However, it was only recently that the mechanism(s) involved in the stimulation of protein synthesis by leucine has begun to be defined. Studies performed in our laboratory during the past few years have revealed that oral… CONTINUE READING
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