Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway.

@article{Bonni1997RegulationOG,
  title={Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway.},
  author={Azad Bonni and Yu Sun and Mireya Nadal-Vicens and Apoorva Bhatt and David A. Frank and Irina Rozovsky and Neil I Stahl and George D. Yancopoulos and Michael E. Greenberg},
  journal={Science},
  year={1997},
  volume={278 5337},
  pages={
          477-83
        }
}
A mechanism by which members of the ciliary neurotrophic factor (CNTF)-leukemia inhibitory factor cytokine family regulate gliogenesis in the developing mammalian central nervous system was characterized. Activation of the CNTF receptor promoted differentiation of cerebral cortical precursor cells into astrocytes and inhibited differentiation of cortical precursors along a neuronal lineage. Although CNTF stimulated both the Janus kinase-signal transducer and activator of transcription (JAK-STAT… CONTINUE READING

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