Regulation of glial cell line-derived neurotrophic factor release from rat C6 glioblastoma cells.

@article{Verity1998RegulationOG,
  title={Regulation of glial cell line-derived neurotrophic factor release from rat C6 glioblastoma cells.},
  author={Adrian Verity and T L Wyatt and B Hajos and R. M. Eglen and Preston A. Baecker and Randolph M. Johnson},
  journal={Journal of neurochemistry},
  year={1998},
  volume={70 2},
  pages={531-9}
}
We have monitored glial cell line-derived neurotrophic factor (GDNF) secretion from rat C6 glioblastoma cells by ELISA. Representative cytokines, neurotrophins, growth factors, neuropeptides, and pharmacological agents were tested for their ability to modulate GDNF release. Whereas most factors tested had minimal effect, a 24-h treatment with fibroblast growth factor-1, -2, or -9 elevated secreted GDNF protein levels five- to 10-fold. The proinflammatory cytokines interleukin-1beta, interleukin… CONTINUE READING

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