Regulation of genome rearrangement events during lymphocyte differentiation.

@article{Alt1986RegulationOG,
  title={Regulation of genome rearrangement events during lymphocyte differentiation.},
  author={Frederick W Alt and T. Keith Blackwell and Ronald A. Depinho and Michael G. Reth and George D. Yancopoulos},
  journal={Immunological reviews},
  year={1986},
  volume={89},
  pages={5-30}
}
Analyses of A-MuLV transformed cell lines have provided fundamental insights into the molecular mechanisms which control the rearrangement events leading to the expression of specific antigen receptor genes. These studies have clearly indicated that tissue-specific, developmental stage-specific, and allelically excluded assembly of Ig H and L chain and TCR… CONTINUE READING