Regulation of gene expression via retrotransposon insertions and the noncoding RNA 4.5S RNAH.

@article{Ishida2015RegulationOG,
  title={Regulation of gene expression via retrotransposon insertions and the noncoding RNA 4.5S RNAH.},
  author={Kentaro Ishida and Kenjyo Miyauchi and Yuko Kimura and Mari Mito and Shunpei Okada and Tsutomu Suzuki and Shinichi Nakagawa},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2015},
  volume={20 11},
  pages={887-901}
}
Short interspersed elements (SINEs) comprise a significant portion of mammalian genomes and regulate gene expression through a variety of mechanisms. Here, we show that Myodonta clade-specific 4.5S RNAH (4.5SH), an abundant nuclear noncoding RNA that is highly homologous to the retrotransposon SINE B1, controls the expression of reporter gene that contains the antisense insertion of SINE B1 via nuclear retention. The depletion of endogenous 4.5SH with antisense oligonucleotides neutralizes the… CONTINUE READING