Regulation of gene expression in melanoma: New approaches for treatment

@article{Leslie2005RegulationOG,
  title={Regulation of gene expression in melanoma: New approaches for treatment},
  author={M. Leslie and M. Bar‐eli},
  journal={Journal of Cellular Biochemistry},
  year={2005},
  volume={94}
}
The molecular changes associated with the transition of melanoma cells from radial growth phase (RGP) to vertical growth phase (VGP, metastatic phenotype) are not yet well defined. We have demonstrated that the progression of human melanoma is associated with loss of expression of the transcription factor AP‐2. In metastatic melanoma cells, this loss resulted in overexpression of MCAM/MUC18, MMP‐2, the thrombin receptor (PAR‐1), and lack of c‐KIT expression. The transition from RGP to VGP is… Expand
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