Regulation of gene expression by internal ribosome entry sites or cryptic promoters: the eIF4G story.

@article{Han2002RegulationOG,
  title={Regulation of gene expression by internal ribosome entry sites or cryptic promoters: the eIF4G story.},
  author={Baoguang Han and Jian-Ting Zhang},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 21},
  pages={7372-84}
}
As an alternative to the scanning mechanism of initiation, the direct-internal-initiation mechanism postulates that the translational machinery assembles at the AUG start codon without traversing the entire 5' untranslated region (5'-UTR) of the mRNA. Although the existence of internal ribosome entry sites (IRESs) in viral mRNAs is considered to be well established, the existence of IRESs in cellular mRNAs has recently been challenged, in part because when testing is carried out using a… CONTINUE READING

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