Regulation of gene expression by hypertonicity.

@article{Burg1997RegulationOG,
  title={Regulation of gene expression by hypertonicity.},
  author={M. Burg and E. D. Kwon and D. K{\"u}ltz},
  journal={Annual review of physiology},
  year={1997},
  volume={59},
  pages={
          437-55
        }
}
Adaptation of cells to hypertonicity often involves changes in gene expression. Since the concentration of salt in the interstitial fluid surrounding renal inner medullary cells varies with operation of the renal concentrating mechanism and generally is very high, the adaptive mechanisms of these cells are of special interest. Renal medullary cells compensate for hypertonicity by accumulating variable amounts of compatible organic osmolytes, including sorbitol, myo-inositol, glycine betaine… Expand
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  • 2001
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Hypertonic activation of BGT1 in renal cells requires de novo protein synthesis and microtubule-dependent trafficking of additional transporters to the cell surface once microtubules repolymerized. Expand
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Present knowledge of how cell volume changes regulate their expression and how the resultant gene products interfere with cellular function are summarized in this review. Expand
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TLDR
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