Regulation of gene expression by hypertonicity.

@article{Burg1997RegulationOG,
  title={Regulation of gene expression by hypertonicity.},
  author={Maurice B. Burg and Eugene D. Kwon and Dietmar K{\"u}ltz},
  journal={Annual review of physiology},
  year={1997},
  volume={59},
  pages={
          437-55
        }
}
Adaptation of cells to hypertonicity often involves changes in gene expression. Since the concentration of salt in the interstitial fluid surrounding renal inner medullary cells varies with operation of the renal concentrating mechanism and generally is very high, the adaptive mechanisms of these cells are of special interest. Renal medullary cells compensate for hypertonicity by accumulating variable amounts of compatible organic osmolytes, including sorbitol, myo-inositol, glycine betaine… 

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