Regulation of gene expression by cyclic GMP.

  title={Regulation of gene expression by cyclic GMP.},
  author={Renate B Pilz and Darren E. Casteel},
  journal={Circulation research},
  volume={93 11},
Cyclic GMP, produced in response to nitric oxide and natriuretic peptides, is a key regulator of vascular smooth muscle cell contractility, growth, and differentiation, and is implicated in opposing the pathophysiology of hypertension, cardiac hypertrophy, atherosclerosis, and vascular injury/restenosis. cGMP regulates gene expression both positively and negatively at transcriptional as well as at posttranscriptional levels. cGMP-regulated transcription factors include the cAMP-response element… CONTINUE READING


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