Regulation of gene expression by CAR: an update

  title={Regulation of gene expression by CAR: an update},
  author={Kaoru Kobayashi and Mari Hashimoto and Paavo Honkakoski and Masahiko Negishi},
  journal={Archives of Toxicology},
The constitutive androstane receptor (CAR), a member of the nuclear receptor superfamily, is a well-known xenosensor that regulates hepatic drug metabolism and detoxification. CAR activation can be elicited by a large variety of xenobiotics, including phenobarbital (PB) which is not a directly binding CAR ligand. The mechanism of CAR activation is complex and involves translocation from the cytoplasm into the nucleus, followed by further activation steps in the nucleus. Recently, epidermal… CONTINUE READING