Regulation of gene expression and cocaine reward by CREB and ΔFosB

@article{McClung2003RegulationOG,
  title={Regulation of gene expression and cocaine reward by CREB and ΔFosB},
  author={Colleen A McClung and Eric J Nestler},
  journal={Nature Neuroscience},
  year={2003},
  volume={6},
  pages={1208-1215}
}
ΔFosB (a truncated form of FosB) and CREB (cAMP response element binding protein) are transcription factors induced in the brain's reward pathways after chronic exposure to drugs of abuse. However, their mechanisms of action and the genes they regulate remain unclear. Using microarray analysis in the nucleus accumbens of inducible transgenic mice, we found that CREB and a dominant-negative CREB have opposite effects on gene expression, as do prolonged expression of ΔFosB and the activator… CONTINUE READING

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