Regulation of gene-activation pathways by PIAS proteins in the immune system
@article{Shuai2005RegulationOG, title={Regulation of gene-activation pathways by PIAS proteins in the immune system}, author={Ke Shuai and Bin Liu}, journal={Nature Reviews Immunology}, year={2005}, volume={5}, pages={593-605} }
The protein inhibitor of activated STAT (PIAS) family of proteins has been proposed to regulate the activity of many transcription factors, including signal transducer and activator of transcription proteins (STATs), nuclear factor-κB, SMA- and MAD-related proteins (SMADs), and the tumour-suppressor protein p53. PIAS proteins regulate transcription through several mechanisms, including blocking the DNA-binding activity of transcription factors, recruiting transcriptional corepressors or co…
426 Citations
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