Regulation of gelatinase B production in corneal cells is independent of autocrine IL-1alpha.

  title={Regulation of gelatinase B production in corneal cells is independent of autocrine IL-1alpha.},
  author={Paola Bargagna-mohan and Katherine J. Strissel and Mary Elizabeth Fini},
  journal={Investigative ophthalmology & visual science},
  volume={40 3},
PURPOSE The matrix metalloproteinase gelatinase B is synthesized by cells at the leading edge of the corneal epithelium migrating to heal a wound. Recent data from the authors' laboratory suggest that excessive synthesis contributes to repair defects. The goal of the study reported here was to investigate mechanisms controlling gelatinase B production by corneal epithelial cells. METHODS Freshly isolated cultures of corneal epithelial cells and early passage stromal fibroblasts from rabbit… CONTINUE READING

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Interleukin l a mediates collagenase synthesis stimulated by phorbol myristate acetate

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