Regulation of gastrin and somatostatin secretion by cholinergic and noncholinergic intramural neurons.

@article{Schubert1982RegulationOG,
  title={Regulation of gastrin and somatostatin secretion by cholinergic and noncholinergic intramural neurons.},
  author={Mitchell L. Schubert and Khalil N. Bitar and Gabriel M. Makhlouf},
  journal={The American journal of physiology},
  year={1982},
  volume={243 6},
  pages={G442-7}
}
The regulation of gastrin and somatostatin secretion by intramural neurons was examined in the isolated vascularly perfused rat stomach. The optimal modalities of transmural electrical stimulation of the antrum were established to be 40 V and 10 Hz. Stimulation at increasing cycle durations (0.1-4 ms) caused increasing gastrin secretion that was progressively more resistant to atropine. The maximal gastrin response to 4-ms cycles was equal to the maximal response to methacholine. However, the… CONTINUE READING