Regulation of gastric acid secretion by secretin and serotonin.

@article{Mat1985RegulationOG,
  title={Regulation of gastric acid secretion by secretin and serotonin.},
  author={L. Mat{\'e} and T. Sakamoto and G. Greeley and J. Thompson},
  journal={American journal of surgery},
  year={1985},
  volume={149 1},
  pages={
          40-5
        }
}
We have tested the interaction between serotonin and secretin in pentagastrin-induced gastric acid secretion in six dogs prepared with Thomas gastric and duodenal cannulas. We further examined the effect of methysergide, a serotonin antagonist, on gastric acid secretion. The intravenous administration of serotonin or secretin alone significantly inhibited pentagastrin-induced gastric acid secretion. The combined administration of serotonin and secretin inhibited gastric acid secretion to a… Expand
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