Regulation of gamma-aminobutyric acid synthesis in the brain.

@article{Martin1993RegulationOG,
  title={Regulation of gamma-aminobutyric acid synthesis in the brain.},
  author={David L. Martin and Karin Rimvall},
  journal={Journal of neurochemistry},
  year={1993},
  volume={60 2},
  pages={
          395-407
        }
}
gamma-Aminobutyric acid (GABA) is synthesized in brain in at least two compartments, commonly called the transmitter and metabolic compartments, and because regulatory processes must serve the physiologic function of each compartment, the regulation of GABA synthesis presents a complex problem. Brain contains at least two molecular forms of glutamate decarboxylase (GAD), the principal synthetic enzyme for GABA. Two forms, termed GAD65 and GAD67, are the products of two genes and differ in… CONTINUE READING

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