Corpus ID: 21469061

Regulation of gamma-aminobutyric acid metabolism in different brain structures by cholinergic and adrenergic drugs.

@article{Balakleevsky1978RegulationOG,
  title={Regulation of gamma-aminobutyric acid metabolism in different brain structures by cholinergic and adrenergic drugs.},
  author={A. I. Balakleevsky and N. P. Bobrova and N. V. Shevtchenko},
  journal={Annali dell'Istituto superiore di sanita},
  year={1978},
  volume={14 1},
  pages={
          133-8
        }
}
The influence of cholinergic and dopaminergic drugs has been studied on the metabolism of GABA by measuring the levels of GABA and glutamate and the activity of glutamic acid decarbosylase and GABA-aminotransferase in mouse and rat brain and in some rat brain regions. Muscarinic agonists (oxotremorine, arecoline) induce a rapid decrease of GABA level and an increase of its destruction, indicative of an increased activity of GABA synapses in basal ganglia and brain stem. Minor changes in GABA… Expand
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