Regulation of galectins by hypoxia and their relevance in angiogenesis: strategies and methods.

@article{Salatino2015RegulationOG,
  title={Regulation of galectins by hypoxia and their relevance in angiogenesis: strategies and methods.},
  author={Mariana Salatino and Diego Omar Croci and Diego Jose Laderach and Daniel Compagno and Lucas Daniel Gentilini and Tom{\'a}s Dalotto-Moreno and Leonardo Sebasti{\'a}n Dergan-Dylon and Santiago P. M{\'e}ndez-Huergo and Marta A. Toscano and Juan Pablo Cerliani and Gabriel A. Rabinovich},
  journal={Methods in molecular biology},
  year={2015},
  volume={1207},
  pages={293-304}
}
Formation of an aberrant and heterogeneous vascular network is a key pathological event in the multistep process of tumor growth and metastasis. Pro-angiogenic factors are synthesized and released from tumor, stromal, endothelial, and myeloid cells in response to hypoxic and immunosuppressive microenvironments which are commonly found during cancer progression. Emerging data indicate key roles for galectins, particularly galectin-1, -3, -8, and -9 in the regulation of angiogenesis in different… CONTINUE READING