Regulation of galanin in rat sympathetic neurons in vitro.

  title={Regulation of galanin in rat sympathetic neurons in vitro.},
  author={Lars Klimaschewski},
  journal={Neuroscience letters},
  volume={234 2-3},
The neuropeptide galanin is induced in sensory and autonomic neurons after peripheral nerve lesion. Leukemia inhibitory factor (LIF) has been suggested to be involved in the up-regulation of galanin. A direct effect of LIF on galanin content in pure sympathetic neuron cultures dissociated from newborn rat superior cervical ganglia was investigated by radioimmunoassay and immunohistochemistry. Galanin increases in sympathetic neurons during a 12 day culture period in the presence of NGF (10 ng… CONTINUE READING