Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions.

@article{Rauch2010RegulationOF,
  title={Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions.},
  author={Bernhard H Rauch and Anke Claudia Rosenkranz and Swen Ermler and Andreas Boehm and Julia Driessen and Jens Walter Fischer and Atsuhiro Sugidachi and Joseph A. Jakubowski and Karsten Schroer},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2010},
  volume={30 12},
  pages={2434-42}
}
OBJECTIVE The platelet P2Y12 ADP receptor is a well-known target of thienopyridine-type antiplatelet drugs. This study is the first to describe increased transcriptional expression of a functionally active P2Y12 in response to thrombin in human vascular smooth muscle cells (SMC). METHODS AND RESULTS On exposure to thrombin, P2Y12 mRNA was transiently increased, whereas total protein and cell surface expression of P2Y12 were markedly increased within 6 hours and remained elevated over 24 hours… CONTINUE READING