Regulation of fructose, 1,6-bisphosphatase by histidine under gluconeogenic conditions.


Fructose 1,6-bisphosphatase (EC requires a free divalent metal and a metal chelate for optimum activity in the neutral pH range. The latter requirement can be satisfied by histidine, which appears to function as the chelating metabolite in vivo. Under fasting conditions, the concentrations of histidine in rabbit liver vary in the range required… (More)


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