Regulation of flagellar dynein by the axonemal central apparatus.

  title={Regulation of flagellar dynein by the axonemal central apparatus.},
  author={Elizabeth F. Smith},
  journal={Cell motility and the cytoskeleton},
  volume={52 1},
Numerous studies indicate that the central apparatus, radial spokes, and dynein regulatory complex form a signaling pathway that regulates dynein activity in eukaryotic flagella. This regulation involves the action of several kinases and phosphatases anchored to the axoneme. To further investigate the role of the central apparatus in this signaling pathway, we have taken advantage of a microtubule-sliding assay to assess dynein activity in central apparatus defective mutants of Chlamydomonas… CONTINUE READING
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