Regulation of fibronectin alternative splicing by a basement membrane-like extracellular matrix.

@article{Srebrow2002RegulationOF,
  title={Regulation of fibronectin alternative splicing by a basement membrane-like extracellular matrix.},
  author={Anabella Srebrow and Mat{\'i}as Blaustein and Alberto R. Kornblihtt},
  journal={FEBS letters},
  year={2002},
  volume={514 2-3},
  pages={
          285-9
        }
}
Hepatocytes are the source of plasma fibronectin (FN) which lacks the alternatively spliced EDI segment, distinctive of oncofetal FN. When hepatic or other epithelial cells are cultured on plastic, EDI inclusion is triggered. Here we report that EDI inclusion is inhibited when hepatic cells are cultured on a basement membrane-like extracellular matrix (ECM), demonstrating a new role for the ECM in the control of gene expression. The effect is duplicated by collagen IV and laminin but not by… CONTINUE READING

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

EDA Fibronectin in Keloids Create a Vicious Cycle of Fibrotic Tumor Formation.

  • The Journal of investigative dermatology
  • 2015
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Regulation of fibronectin by thyroid hormone receptors.

  • Journal of molecular endocrinology
  • 2004
VIEW 1 EXCERPT
CITES BACKGROUND