Regulation of ferrochelatase gene expression by hypoxia.

  title={Regulation of ferrochelatase gene expression by hypoxia.},
  author={Yunying L Liu and Sonny O. Ang and Douglas A. Weigent and Josef T Prchal and Joseph R. Bloomer},
  journal={Life sciences},
  volume={75 17},
Ferrochelatase (FECH), the last enzyme of the heme biosynthetic pathway, catalyzes the insertion of iron into protoporphyrin to form heme. This pathway provides heme for hemoglobin and other essential hemoproteins. The regulatory role of oxygen in the pathway has not been clearly established. In this study, we examined whether FECH gene expression is upregulated during hypoxia by a mechanism which involves the hypoxia-inducible factor 1 (HIF-1). Two HIF-1 binding motifs were identified within… CONTINUE READING


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