Regulation of ferritin: a specific role for interferon-alpha (IFN-alpha)? The acute phase response in patients treated with IFN-alpha-2b.

@article{Stam2002RegulationOF,
  title={Regulation of ferritin: a specific role for interferon-alpha (IFN-alpha)? The acute phase response in patients treated with IFN-alpha-2b.},
  author={Tanja C. Stam and Antonius J G Swaak and Wim H. J. Kruit and A. M. M. Eggermont},
  journal={European journal of clinical investigation},
  year={2002},
  volume={32 Suppl 1},
  pages={79-83}
}
BACKGROUND Adult onset of Still's disease is characterized by very high serum ferritin levels, in disproportion with other acute phase proteins (APPs). Because interferon-alpha (IFN-alpha) was observed to cause hyperferritinaemia in three healthy people without increase of other APPs, we hypothesized that IFN-alpha stimulates specifically the synthesis of ferritin. To test this hypothesis, we studied ferritin and other APP levels in patients treated with IFN-alpha. PATIENTS AND METHODS… CONTINUE READING

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