Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways.

@article{Goldberg2009RegulationOF,
  title={Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways.},
  author={Ira J Goldberg and Robert H Eckel and Nada A. Abumrad},
  journal={Journal of lipid research},
  year={2009},
  volume={50 Suppl},
  pages={S86-90}
}
Cells obtain FAs either from LPL-catalyzed hydrolysis of lipoprotein triglyceride or from unesterified FFAs associated with albumin. LPL also influences uptake of esterified lipids such as cholesteryl and retinyl esters that are not hydrolyzed in the plasma. This process might not involve LPL enzymatic activity. LPL is regulated by feeding/fasting, insulin, and exercise. Although a number of molecules may affect cellular uptake of FFAs, the best characterized is CD36. Genetic deletion of this… CONTINUE READING