Regulation of fatty acid synthase at transcriptional and post-transcriptional levels in rat liver.

@article{Kim1992RegulationOF,
  title={Regulation of fatty acid synthase at transcriptional and post-transcriptional levels in rat liver.},
  author={K. S. Kim and Sae Woong Park and Young Sam Kim},
  journal={Yonsei medical journal},
  year={1992},
  volume={33 3},
  pages={199-208}
}
The regulation of fatty acid synthase in rat liver was investigated at transcriptional and post-transcriptional levels. When rats were fasted for 3 days and refed on a high-carbohydrate diet, the amounts of FAS in liver cytosol began to increase at 12 hours and further increased until 48 hours. The amount of mRNA for FAS began to increase at 6 hours and reached to a maximum level at 12 hours, indicating that the expression of mRNA for FAS precedes the increase of FAS protein pool. After 12… CONTINUE READING