Regulation of fatty acid elongation and initiation by acyl-acyl carrier protein in Escherichia coli.

@article{Heath1996RegulationOF,
  title={Regulation of fatty acid elongation and initiation by acyl-acyl carrier protein in Escherichia coli.},
  author={Richard J. Heath and Charles O Rock},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 4},
  pages={1833-6}
}
Long chain acyl-acyl carrier protein (acyl-ACP) has been implicated as a physiological inhibitor of fatty acid biosynthesis since acyl-ACP degradation by thioesterase overexpression leads to constitutive, unregulated fatty acid production. The biochemical targets for acyl-ACP inhibition were unknown, and this work identified two biosynthetic enzymes that were sensitive to acyl-ACP feedback inhibition. Palmitoyl-ACP inhibited the incorporation of [14C]malonyl-CoA into long chain fatty acids in… CONTINUE READING
59 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 59 extracted citations

Similar Papers

Loading similar papers…