Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor kappaB.

@article{Kasibhatla1999RegulationOF,
  title={Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor kappaB.},
  author={Shailaja Kasibhatla and Laurent Genestier and Douglas R Green},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 2},
  pages={987-92}
}
T cell receptor engagement activates transcription factors important for cytokine gene regulation. Additionally, this signaling pathway also leads to activation-induced apoptosis in T lymphocytes that is dependent on FasL transcription and expression. Here we demonstrate that nuclear factor kappaB (NF-kappaB), which is involved in the transcriptional regulation of many cytokine genes expressed in activated lymphocytes, also plays a role in T cell activation-induced FasL expression. Inhibition… CONTINUE READING

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