Regulation of expression of the human lymphocyte activation gene-3 (LAG-3) molecule, a ligand for MHC class II

@article{Bruniquel1998RegulationOE,
  title={Regulation of expression of the human lymphocyte activation gene-3 (LAG-3) molecule, a ligand for MHC class II},
  author={Denis Bruniquel and Nathalie Borie and Sigrid Hannier and Frederic Triebel},
  journal={Immunogenetics},
  year={1998},
  volume={48},
  pages={116-124}
}
Abstract The lymphocyte activation gene-3 (LAG-3), a major histocompatibility complex (MHC) class II ligand evolutionarily related to CD4, is expressed exclusively in activated T and NK lymphocytes and seems to play a role in regulating the evolving immune response. We first determined that surface LAG-3 expression on activated human T cells is upregulated by certain cytokines (IL-2, IL-7, IL-12) and not by others (IL-4, IL-6, IL-10, TNF-α, TNF-β, IFN-γ). Surface LAG-3 expression correlated… Expand
Lymphocyte activation gene-3 : the expression and function in the immune system
TLDR
The main finding of this work is that, unlike previously thought, LAG-3 expression is not only limited to activated T and NK cells, but can also be induced on B cells and DCs, which suggests a novel co-stimulatory function of L AG-3 on APCs. Expand
Lymphocyte activation gene-3, a MHC class II ligand expressed on activated T cells, stimulates TNF-alpha and IL-12 production by monocytes and dendritic cells.
TLDR
Similar to CD40L, LAG-3 may be involved in the proinflammatory activity of cytokine-activated bystander T cells and most importantly it may directly activate DC. Expand
CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling.
TLDR
Results show that CD3/TCR complex-associated LAG-3 molecules can play an active role in negatively regulating the CD3 /TCR activation pathway, and suggest that L AG-3 is an inhibitory receptor in activated T lymphocytes. Expand
Lymphocyte activation gene-3 expression defines a discrete subset of HIV-specific CD8+ T cells that is associated with lower viral load.
TLDR
A new population of HIV-specific LAG3(+)CD8(+) T cells expressing LAG-3 is described and additional mechanisms of immune regulation in chronic HIV infection are proposed. Expand
LAG-3 Regulates Plasmacytoid Dendritic Cell Homeostasis1
TLDR
The data suggests that LAG-3 plays an important but selective cell intrinsic and cell extrinsic role in pDC biology, and may serve as a key functional marker for their study of homeostatic reciprocity between T cells and pDCs. Expand
T Lymphocytes infiltrating various tumour types express the MHC class II ligand lymphocyte activation gene-3 (LAG-3): role of LAG-3/MHC class II interactions in cell-cell contacts.
TLDR
Support is provided for a role for TIL-expressed LAG-3 in the engagement of class II molecules on APCs, thereby contributing to APC activation and Th1/Tc1 commitment, without downregulating cytotoxicity. Expand
Functionally Distinct LAG-3 and PD-1 Subsets on Activated and Chronically Stimulated CD8 T Cells1
TLDR
The results imply that signaling through the PD-1 and LAG-3 pathways have distinct functional consequences to CD8 T cells under tolerizing conditions and manipulation of both Ag and cytokine signaling can influence CD8 tolerance through L AG-3 andPD-1. Expand
Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3
TLDR
It is demonstrated that fibrinogen-like protein 1 (FGL1), a liver-secreted protein, is a major LAG-3 functional ligand independent from MHC-II, revealing an immune evasion mechanism and have implications for the design of cancer immunotherapy. Expand
Understanding LAG-3 Signaling
TLDR
The current understanding of L AG-3 signaling and its role in LAG-3 functions is summarized, from its mechanisms of action to clinical applications. Expand
Expression regulation of co-inhibitory molecules on human natural killer cells in response to cytokine stimulations.
TLDR
It is shown that the expressions of co-inhibitors on NK cells, including LAG-3, PD-1, and TIGIT, are differently regulated by cytokines IL-10,IL-12, IL-15, IFN-α, andTGF-β, providing an initial information on the expression regulation ofCo-Inhibitors in human NK cells. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 36 REFERENCES
Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens
TLDR
It is demonstrated that rosette formation between LAG-3-transfected COS-7 cells and human leukocyte antigen (HLA) class II-bearing B lymphocytes is specifically dependent on L AG-3/HLA class II interaction. Expand
Characterization of the major histocompatibility complex class II binding site on LAG-3 protein.
TLDR
The lymphocyte activation gene-3, selectively transcribed in human activated T and NK cells, encodes a ligand for major histocompatibility complex (MHC) class II molecules, and residues on the membrane-distal, CDR1-2-containing top face of D1 that are essential for either binding or repulsing MHC class II proteins are found. Expand
Lymphocyte‐activation gene 3/major histocompatibility complex class II interaction modulates the antigenic response of CD4+ T lymphocytes
TLDR
The present analysis reveals a modulating effect of anti‐LAG‐3 mAb, mediated specifically on antigen‐dependent, MHC class II‐restricted responses of CD4+ T cell lines, and these results support the view that LAG‐ 3/MHCclass II interaction down‐regulates antigen‐ dependent stimulation of CD 4+ T lymphocytes. Expand
Genomic organization of the human LAG-3/CD4 locus
TLDR
There is a need for coordinated expression of both LAG-3 and MHC class II molecules in tissues in order to down-regulate the ongoing immune response and the physiological role of L AG-3 protein is still unclear. Expand
Expression and release of LAG‐3‐encoded protein by human CD4+ T cells are associated with IFN‐γ production
The lymphocyte activation gene (LAG) ‐3 is a member of the immunoglobulin superfamily that is selectively transcribed in human activated T and NK cells. In this work, the possibility that LAG‐3Expand
T cell major histocompatibility complex class II molecules down‐regulate CD4+ T cell clone responses following LAG‐3 binding
TLDR
Functional studies indicate that T cell MHC class II molecules down‐regulate T cell proliferation following LAG‐3 binding and suggest a role for L AG‐3 in the control of the CD4+ T cell response. Expand
Opposite role for interleukin‐4 and interferon‐γ on CD30 and lymphocyte activation gene‐3 (LAG‐3) expression by activated naive T cells
TLDR
Data suggest that CD30 expression is dependent on the presence of IL‐4, whereas LAG‐3 expression isdependent on the production of IFN‐γ during the lineage commitment of human naive T cells. Expand
Elf-1 binds to a critical element in a second CD4 enhancer.
TLDR
This work presents the identification of a second transcriptional enhancer in the murine CD4 locus 24 kb upstream of the CD4 promoter and finds that the Ets consensus site is crucial for enhancer activity and that the recently identified Ets factor, Elf-1, is a dominant protein in T-cell nuclear extracts that binds to this site. Expand
CTLA-4 is a second receptor for the B cell activation antigen B7
TLDR
These findings provide direct evidence that, like its structural homologue CD28, CTLA- 4 is able to bind the B7 counter-receptor on activated B cells. Expand
LAG-3, a novel lymphocyte activation gene closely related to CD4
TLDR
The compared analysis of LAG-3 and CD4, with respect to both their peptidic sequence as well as their exon/intron organization, indicated that the two molecules are closely related. Expand
...
1
2
3
4
...