Regulation of expression of the CD11b and CD18 subunits of the neutrophil adherence receptor during human myeloid differentiation.

@article{Hickstein1989RegulationOE,
  title={Regulation of expression of the CD11b and CD18 subunits of the neutrophil adherence receptor during human myeloid differentiation.},
  author={Dennis Durand Hickstein and Anthony L. Back and Steven John Collins},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 36},
  pages={21812-7}
}
The receptor on human myeloid cells that mediates cellular adherence consists of a heterodimer complex (designated CD11b/CD18). This receptor complex plays a critical role in leukocyte chemotaxis, adherence to vascular endothelium, and phagocytosis. We investigated expression of the CD11b subunit of this adherence receptor complex in various leukocyte populations. As previously described for the CD18 subunit, enhanced CD11b surface antigen and mRNA expression are present in peripheral blood… CONTINUE READING