Regulation of expression of stromyelysin-1 by proinflammatory cytokines in mouse brain astrocytes.

@article{WitekZawada2003RegulationOE,
  title={Regulation of expression of stromyelysin-1 by proinflammatory cytokines in mouse brain astrocytes.},
  author={B Witek-Zawada and Aleksander Koj},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2003},
  volume={54 4},
  pages={489-96}
}
Stromelysin-1 belongs to matrix metalloproteinases responsible for proteolytic degradation of extracellular matrix in many tissues during various diseases, especially those involving inflammation. We studied the induced expression of stromelysin-1 in primary cultures of mouse brain astrocytes stimulated with various cytokines and cellular growth factors. Interleukin-1-beta (IL-1beta), tumor necrosis factor alpha (TNFalpha) and a mixture of IL-1, TNF and epidermal growth factor (EGF… CONTINUE READING