Regulation of estrogen receptors and MMP-2 expression by estrogens in human retinal pigment epithelium.

@article{MarinCastao2003RegulationOE,
  title={Regulation of estrogen receptors and MMP-2 expression by estrogens in human retinal pigment epithelium.},
  author={Maria Encarna Marin-Casta{\~n}o and Sharon J. Elliot and Mylen Potier and Michael Karl and Liliane J Striker and Gary E. Striker and Karl G. Csaky and Scott W. Cousins},
  journal={Investigative ophthalmology & visual science},
  year={2003},
  volume={44 1},
  pages={50-9}
}
PURPOSE Age-related macular degeneration (ARMD) is characterized by progressive thickening and accumulation of various lipid-rich extracellular matrix (ECM) deposits under the retinal pigment epithelium (RPE). ECM dysregulation probably contributes to the pathologic course of ARMD. By activating estrogen receptors (ERs), estrogens regulate the expression of genes relevant in the turnover of ECM, among them matrix metalloproteinase (MMP)-2. Estrogen deficiency may predispose to dysregulated… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 44 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Crosstalk between stat 5b and estrogen receptor- and in mammary epithelial cells

L Bjornstrom, E Kilic, M Normand, MG Parker, M. Sjoberg
J Mol Endocrinol • 2001

Presence of estrogen receptor type in human retina

C Munaut, V Lambert, A Noel
Br J Ophthalmol • 2001

Synergistic activation of the serotonin-1A receptor by nuclear factor- and estrogen

S Wissink, B Van der Burg, BS Katzenellenbogen, Saag. van der
Mol Endocrinol • 2001

Similar Papers

Loading similar papers…