Regulation of error-prone translesion synthesis by Spartan/C1orf124

Abstract

Translesion synthesis (TLS) employs low fidelity polymerases to replicate past damaged DNA in a potentially error-prone process. Regulatory mechanisms that prevent TLS-associated mutagenesis are unknown; however, our recent studies suggest that the PCNA-binding protein Spartan plays a role in suppression of damage-induced mutagenesis. Here, we show that… (More)
DOI: 10.1093/nar/gks1267

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