Regulation of ergosterol biosynthesis and sterol uptake in a sterol-auxotrophic yeast.

@article{Lorenz1987RegulationOE,
  title={Regulation of ergosterol biosynthesis and sterol uptake in a sterol-auxotrophic yeast.},
  author={R. Lorenz and L. Parks},
  journal={Journal of bacteriology},
  year={1987},
  volume={169 8},
  pages={
          3707-11
        }
}
  • R. Lorenz, L. Parks
  • Published 1987
  • Medicine, Biology
  • Journal of bacteriology
  • Inhibition of sterol uptake in Saccharomyces cerevisiae sterol auxotroph FY3 (alpha hem1 erg7 ura) by delta-aminolevulinic acid (ALA) is dependent on the ability of the organism to synthesize heme from ALA. Sterol-depleted cells not exposed to ALA or strain PFY3 cells, with a double heme mutation, exposed to ALA did not exhibit inhibition of sterol uptake. Addition of ALA to sterol-depleted FY3 stimulated production of a high endogenous concentration of 2,3-oxidosqualene (25.55 micrograms mg-1… CONTINUE READING
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