Regulation of epithelial sodium channels in urokinase plasminogen activator deficiency.

@article{Chen2014RegulationOE,
  title={Regulation of epithelial sodium channels in urokinase plasminogen activator deficiency.},
  author={Zaixing Chen and Runzhen Zhao and Meimi Zhao and Xinrong Liang and Deepa Bhattarai and Rohan Dhiman and Shwetha Kumari Shetty and Steven Idell and Hong-Long Ji},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2014},
  volume={307 8},
  pages={
          L609-17
        }
}
Epithelial sodium channels (ENaC) govern transepithelial salt and fluid homeostasis. ENaC contributes to polarization, apoptosis, epithelial-mesenchymal transformation, etc. Fibrinolytic proteases play a crucial role in virtually all of these processes and are elaborated by the airway epithelium. We hypothesized that urokinase-like plasminogen activator (uPA) regulates ENaC function in airway epithelial cells and tested that possibility in primary murine tracheal epithelial cells (MTE). Both… CONTINUE READING

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