Regulation of epithelial differentiation and proliferation by the stroma – a role for the retinoblastoma protein

@inproceedings{Pickard2012RegulationOE,
  title={Regulation of epithelial differentiation and proliferation by the stroma – a role for the retinoblastoma protein},
  author={Adam Pickard and Ann-Christin Cichon and Craig W Menges and Daksha Patel and Dennis J. McCance},
  booktitle={The Journal of investigative dermatology},
  year={2012}
}
Signaling between the epithelium and stromal cells is crucial for growth, differentiation, and repair of the epithelium. Although the retinoblastoma protein (Rb) is known to regulate the growth of keratinocytes in a cell-autonomous manner, here we describe a function of Rb in the stromal compartment. We find that Rb depletion in fibroblasts leads to inhibition of differentiation and enhanced proliferation of the epithelium. Analysis of conditioned medium identified that keratinocyte growth… CONTINUE READING

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