Regulation of epidermin biosynthetic genes by EpiQ.

  title={Regulation of epidermin biosynthetic genes by EpiQ.},
  author={Andreas Peschel and J{\"u}rgen Augustin and Thomas Kupke and Stefan Stevanovi{\'c} and Friedrich G{\"o}tz},
  journal={Molecular microbiology},
  volume={9 1},
We investigated the role of epiQ in the biosynthesis of the lantibiotic epidermin. epiQ was essential for epidermin production. It was shown that EpiQ controls epidermin production by transcriptionally activating the epiA promoter, used for transcription of most of the epidermin biosynthetic genes. Additional copies of epiQ increased epidermin production in the epidermin-producing wild-type strain Staphylococcus epidermidis Tü3298. The epiA promoter region was characterized by primer extension… CONTINUE READING

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