Regulation of eosinophilopoiesis in a murine model of asthma.

  title={Regulation of eosinophilopoiesis in a murine model of asthma.},
  author={Mary Beth Hogan and David N. Weissman and Ann F. Hubbs and Laura F. Gibson and Debra Piktel and Kenneth S. Landreth},
  journal={Journal of immunology},
  volume={171 5},
Eosinophilic inflammation plays a key role in tissue damage that characterizes asthma. Eosinophils are produced in bone marrow and recent observations in both mice and humans suggest that allergen exposure results in increased output of eosinophils from hemopoietic tissue in individuals with asthma. However, specific mechanisms that alter eosinophilopoiesis in this disease are poorly understood. The current study used a well-characterized murine animal model of asthma to evaluate alterations of… CONTINUE READING


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