Regulation of energy metabolism by long-chain fatty acids.

  title={Regulation of energy metabolism by long-chain fatty acids.},
  author={Manabu Nakamura and Barbara E Yudell and Juan J Loor},
  journal={Progress in lipid research},
In mammals, excess energy is stored primarily as triglycerides, which are mobilized when energy demands arise. This review mainly focuses on the role of long chain fatty acids (LCFAs) in regulating energy metabolism as ligands of peroxisome proliferator-activated receptors (PPARs). PPAR-alpha expressed primarily in liver is essential for metabolic adaptation to starvation by inducing genes for beta-oxidation and ketogenesis and by downregulating energy expenditure through fibroblast growth… CONTINUE READING
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