Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

  title={Regulation of endothelium-derived nitric oxide production by the protein kinase Akt},
  author={David Fulton and J. -P. Gratton and Timothy J. McCabe and Jason Fontana and Yasushi Fujio and Kenneth Walsh and Thomas F. Franke and Andreas Papapetropoulos and William C Sessa},
Endothelial nitric oxide synthase (eNOS) is the nitric oxide synthase isoform responsible for maintaining systemic blood pressure, vascular remodelling and angiogenesis. eNOS is phosphorylated in response to various forms of cellular stimulation but the role of phosphorylation in the regulation of nitric oxide (NO) production and the kinase(s) responsible are not known. Here we show that the serine/threonine protein kinase Akt (protein kinase B) can directly phosphorylate eNOS on serine 1179… CONTINUE READING
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