Regulation of endothelial permeability by second messengers.

  title={Regulation of endothelial permeability by second messengers.},
  author={Alma Siflinger-Birnboim and Asrar B. Malik},
  journal={New horizons},
  volume={4 1},
The mechanisms by which mediators such as oxidants released by neutrophil (PMN) activation increase endothelial permeability are poorly understood. The focus of this article is to identify some of these mechanisms. Studies using endothelial cell monolayers in culture have shown that PMN activation increases endothelial permeability both in the presence and absence of PMN-endothelial monolayer contact. Hydrogen peroxide (H2O2), an oxidant released by PMN activation, plays an important role in… CONTINUE READING

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