Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.

  title={Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.},
  author={Nicholas J. Alp and Keith M. Channon},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={24 3},
Nitric oxide (NO), produced by endothelial nitric oxide synthase (eNOS), is a key signaling molecule in vascular homeostasis. Loss of NO bioavailability due to reduced synthesis and increased scavenging by reactive oxygen species is a cardinal feature of endothelial dysfunction in vascular disease states. The pteridine cofactor tetrahydrobiopterin (BH4) has emerged as a critical determinant of eNOS activity: when BH4 availability is limiting, eNOS no longer produces NO but instead generates… CONTINUE READING
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Gene transfer of human guanosine 5 -triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension

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