Regulation of endothelial cell plasticity by TGF-β

  title={Regulation of endothelial cell plasticity by TGF-β},
  author={Laurens van Meeteren and Peter Ten Dijke},
  booktitle={Cell and Tissue Research},
Recent evidence has demonstrated that endothelial cells can have a remarkable plasticity. By a process called Endothelial-to-Mesenchymal Transition (EndMT) endothelial cells convert to a more mesenchymal cell type that can give rise to cells such as fibroblasts, but also bone cells. EndMT is essential during embryonic development and tissue regeneration. Interestingly, it also plays a role in pathological conditions like fibrosis of organs such as the heart and kidney. In addition, EndMT… CONTINUE READING
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Hierck BP (2011b) Tgfβ/Alk5 signaling is required for shear stress induced klf2 expression in embryonic endothelial cells

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