Regulation of endothelial cell adhesion by profilin

  title={Regulation of endothelial cell adhesion by profilin},
  author={Nicanor I. Moldovan and Emily E. Milliken and Kaikobad Irani and Jie Chen and Richard H. Sohn and Toren Finkel and Pascal J. Goldschmidt-Clermont},
  journal={Current Biology},
BACKGROUND Although profilin is believed to be an essential regulator of the actin cytoskeleton in most cells, its precise role in mammalian cells remains unknown. We have used replication-incompetent adenovirus carrying the human profilin I cDNA as a means rapidly to increase the concentration of profilin in human aortic endothelial cells 12-31-fold above baseline--levels never before achieved in mammalian cells. RESULTS The concentration of filamentous actin was not detectably affected by… CONTINUE READING