Regulation of endoplasmic reticulum turnover by selective autophagy

@article{Khaminets2015RegulationOE,
  title={Regulation of endoplasmic reticulum turnover by selective autophagy},
  author={Aliaksandr Khaminets and Theresa Heinrich and Muriel Mari and Paolo Grumati and Antje K. Huebner and Masato Akutsu and Lutz Liebmann and Alexandra Stolz and S{\'a}ndor Nietzsche and Nicole Koch and Mario Mauthe and Istv{\'a}n Katona and Britta Qualmann and Joachim Weis and Fulvio Reggiori and Ingo Kurth and Christian Andreas H{\"u}bner and Ivan Dikic},
  journal={Nature},
  year={2015},
  volume={522},
  pages={354-358}
}
The endoplasmic reticulum (ER) is the largest intracellular endomembrane system, enabling protein and lipid synthesis, ion homeostasis, quality control of newly synthesized proteins and organelle communication. Constant ER turnover and modulation is needed to meet different cellular requirements and autophagy has an important role in this process. However, its underlying regulatory mechanisms remain unexplained. Here we show that members of the FAM134 reticulon protein family are ER-resident… CONTINUE READING

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