Regulation of endocytosis by phosphatidylinositol 4,5-bisphosphate and ENTH proteins.

@article{Itoh2004RegulationOE,
  title={Regulation of endocytosis by phosphatidylinositol 4,5-bisphosphate and ENTH proteins.},
  author={Toshiki Itoh and Tadaomi Takenawa},
  journal={Current topics in microbiology and immunology},
  year={2004},
  volume={282},
  pages={
          31-47
        }
}
Clathrin-mediated endocytosis starts by a recruitment of endocytic proteins to the plasma membrane to induce invagination of lipid bilayer and subsequent vesicule formation. The recruitment of these components requires PtdIns(4,5)P2, a phosphoinositide on the plasma membrane. Although it is well known that the synthesis as well as the disruption of this lipid is important, recent studies have revealed the indispensable roles of direct interaction between PtdIns(4,5)P2 and the endocytic… CONTINUE READING
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