Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans.

@article{Schubert2011RegulationOE,
  title={Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans.},
  author={Sabrina Schubert and Katherine S. Barker and Sadri Znaidi and Sabrina Schneider and Franziska Dierolf and Nico Dunkel and Malika A{\"i}d and Genevi{\`e}ve Boucher and Peter Rogers and Martine Raymond and Joachim Morschh{\"a}user},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 5},
  pages={2212-23}
}
Constitutive overexpression of the Mdr1 efflux pump is an important mechanism of acquired drug resistance in the yeast Candida albicans. The zinc cluster transcription factor Mrr1 is a central regulator of MDR1 expression, but other transcription factors have also been implicated in MDR1 regulation. To better understand how MDR1-mediated drug resistance is achieved in this fungal pathogen, we studied the interdependence of Mrr1 and two other MDR1 regulators, Upc2 and Cap1, in the control of… CONTINUE READING
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