Regulation of effector and memory T-cell functions by type I interferon.

@article{Huber2011RegulationOE,
  title={Regulation of effector and memory T-cell functions by type I interferon.},
  author={Jonathan P. Huber and Joshua D Farrar},
  journal={Immunology},
  year={2011},
  volume={132 4},
  pages={466-74}
}
Type I interferon (IFN-α/β) is comprised of a family of highly related molecules that exert potent antiviral activity by interfering with virus replication and spread. IFN-α/β secretion is tightly regulated through pathogen sensing pathways that are operative in most somatic cells. However, specialized antigen-presenting plasmacytoid dendritic cells are uniquely equipped with the capacity to secrete extremely high levels of IFN-α/β, suggesting a key role for this cytokine in priming adaptive T… CONTINUE READING

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